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Reproducible, portable, and effcient ancient genome reconstruction with nf-core/eager

The broadening utilisation of ancient DNA to address archaeological, palaeontological, and biological questions is resulting in a rising diversity in the size of laboratories and scale of analyses being performed. In the context of this heterogeneous …

Interpretations of microbial community studies are biased by the selected 16S rRNA gene amplicon sequencing pipeline.

One of the major methods to identify microbial community composition, to unravel microbial population dynamics, and to explore microbial diversity in environmental samples is DNA- or RNA-based 16S rRNA (gene) amplicon sequencing. Subsequent …

DamageProfiler: Fast damage pattern calculation for ancient DNA

In ancient DNA research, the authentication of ancient samples based on specific features remains a crucial step in data analysis. Because of this central importance, researchers lacking deeper programming knowledge should be able to run a basic …

Reproducible, portable, and effcient ancient genome reconstruction with nf-core/eager

The broadening utilisation of ancient DNA (aDNA) to address archaeological, palaeontological, and biological questions is resulting in a rising diversity in the size of laboratories and scale of analyses being performed. In the context of this …

Ten simple rules for providing effective bioinformatics research support

Life scientists are increasingly turning to high-throughput sequencing technologies in their research programs, owing to the enormous potential of these methods. In a parallel manner, the number of core facilities that provide bioinformatics support …

The nf-core framework for community-curated bioinformatics pipelines

The standardization, portability and reproducibility of analysis pipelines are key issues within the bioinformatics community. Most bioinformatics pipelines are designed for use on-premises; as a result, the associated software dependencies and …

Interpretations of microbial community studies are biased by the selected 16S rRNA gene amplicon sequencing pipeline.

One of the major methods to identify microbial community composition, to unravel microbial population dynamics, and to explore microbial diversity in environmental samples is DNA- or RNA-based 16S rRNA (gene) amplicon sequencing. Subsequent …

Potent Antitumor Activity of Liposomal Irinotecan in an Organoid- and CRISPR-Cas9-Based Murine Model of Gallbladder Cancer

Gallbladder cancer is associated with a dismal prognosis, and accurate in vivo models will be elemental to improve our understanding of this deadly disease and develop better treatment options. We have generated a transplantation-based murine model …

MHCquant: Automated and reproducible data analysis for immunopeptidomics

Personalized multi-peptide vaccines are currently discussed intensively for tumor immunotherapy. In order to identify epitopes - short, immunogenic peptides - suitable for eliciting a tumor-specific immune response, human leukocyte antigen …

Challenges of big data integration in the life sciences

Big data has been reported to be revolutionizing many areas of life, including science. It summarizes data that is unprecedentedly large, rapidly generated, heterogeneous, and hard to accurately interpret. This availability has also brought new …